BORDETELLA ADENYLATE CYCLASE TOXIN INHIBITS MONOCYTE-TO-MACROPHAGE TRANSITION AND DEDIFFERENTIATES HUMAN ALVEOLAR MACROPHAGES INTO MONOCYTE-LIKE CELLS

ABSTRACT Monocytes arriving at the site of infection differentiate into functional effector macrophages to replenish the resident sentinel cells.Bordetella pertussis, the pertussis agent, secretes an adenylate cyclase toxin-hemolysin (CyaA) that binds myeloid phagocytes through complement receptor 3 (CD11b/CD18) and swiftly delivers its adenylyl cy

Seasonal influenza activity typically peaks in the winter months but plummeted globally during the current coronavirus disease 2019 (COVID-19) pandemic.Unraveling lessons from influenza’s unprecedented low profile is critical in informing preparedness for incoming influenza seasons.Here, we explored a country-specific inference model to estimate

Emerging antibiotic resistance among mycoplasma microorganisms is of major concern in present times as they cause various diseases in both animals and humans.Mycoplasmoses, infections caused by mycoplasma microorganisms have become common in recent past and have gained importance both due to inability to diagnose and difficulty to treat.Respiratory

Abstract Background Human microRNAs (miRNAs) have diverse functions in biology, and play a role in nearly every biological process.Here we report that miR-520d-5p (520d-5p) causes undifferentiated cancer cells to adopt benign or normal status in vivo in immunodeficient mice via demethylation and P53 upregulation.Further we found that 520-5p causes